TRP Channel Inhibitors

TRPA1

TRPC3

TRPC4

TRPC5

TRPC6

TRPC7

TRPM8

TRPM2

TRPM3

TRPM4

TRPM7

TRPML1

TRPML2

TRPML3

TRPV1

TRPV2

TRPV3

TRPV4

TRPV6

TRP Channel Inhibitors, Agonists, Antagonists, Activators, Modulators & Ligands

Product Name	TRPA1	TRPC3	TRPC4	TRPC5	TRPC6	TRPC7	TRPM8	TRPM2	TRPM3	TRPM4	TRPM7	TRPML1	TRPML2	TRPML3	TRPV1	TRPV2	TRPV3	TRPV4	TRPV6	Purity
Rosiglitazone				TRPC5, EC₅₀: 30 μM																99.94%
Ponometrep									TRPM3, IC₅₀: 1-10 nM											99.28%
Probenecid																TRPV2				99.94%
GSK1016790A																		TRPV4		99.93%
HC-067047																		TRPV4		99.97%
Anandamide															TRPV1					≥99.0%
GSK2193874																		hTRPV4, IC₅₀: 2 nM rTRPV4, IC₅₀: 40 nM		99.91%
ML-SI3												TRPML1, IC₅₀: 4.7 μM	TRPML2, IC₅₀: 1.7 μM	TRPML3, IC₅₀: 12.5 μM						99.91%
Lazertinib	TRPA1																			99.87%
SB-366791															hTRPV1, IC₅₀: 5.7 nM					99.29%
Icilin							TRPM8													99.26%
CIM0216									TRPM3											99.94%
SET2																TRPV2, IC₅₀: 0.46 μM				99.78%
Dihydrocapsaicin															TRPV1					99.93%
GSK205															TRPV1, EC₅₀: 28 μM			TRPV4, EC₅₀: 21 μM		99.47%
(1R,2R)-ML-SI3												TRPML1, IC₅₀: 1.6 μM	TRPML2, IC₅₀: 2.3 μM	TRPML3, IC₅₀: 12.5 μM						99.79%
JNJ-28583113								TRPM2												98.82%
GSK1702934A		TRPC3																		99.11%
Acoltremon							TRPM8													99.13%
LE135	TRPA1, EC₅₀: 20 μM														TRPV1, EC₅₀: 2.5 μM					99.0%
Englerin A			hTRPC4, EC₅₀: 11.2 nM	hTRPC5, EC₅₀: 7.6 nM																99.50%
TRPM4-IN-2										TRPM4, IC₅₀: 0.16 μM										99.17%
TRPV2-selective blocker 1																TRPV2, IC₅₀: 6.3 μM				99.84%
RQ-00203078							TRPM8, IC₅₀: 5.3 nM (Rat TRPM8 channels) TRPM8, IC₅₀: 8.3 nM (Human TRPM8 channels)											TRPV4, IC₅₀: 10 μM		99.84%
9-Phenanthrol										TRPM4, IC₅₀: 17 μM										99.61%
ML204			TRPC4	TRPC5																98.45%
Rosiglitazone hydrochloride				TRPC5, EC₅₀: 30 μM																99.81%
RN-1734																		hTRPV4, IC₅₀: 2.3 μM rTRPV4, IC₅₀: 3.2 μM mTRPV4, IC₅₀: 5.9 μM		99.75%
Camphor																	TRPV3			98.0%
N-Oleoyldopamine															TRPV1					99.47%
GSK2798745																		hTRPV4, IC₅₀: 1.8 nM rTRPV4, IC₅₀: 1.6 nM		99.80%
Olvanil															TRPV1, EC₅₀: 0.7 nM					≥99.0%
Pyr10		TRPC3, IC₅₀: 0.72 μM																		99.95%
Moringin															TRPV1, EC₅₀: 3.14 μM					99.95%
Tivanisiran sodium															TRPV1
(rel)-ML-SI3												TRPML1, IC₅₀: 3.1 μM	TRPML2, EC₅₀: 3.3 μM	TRPML3, IC₅₀: 28.5 μM						98.94%
SOR-C13																			TRPV6, IC₅₀: 14 nM	99.12%
Sphingosylphosphorylcholine									TRPM3											99.50%
PF-05105679							TRPM8, IC₅₀: 103 nM													99.88%
AP-18	TRPA1, IC₅₀: ~3 μM																			99.61%
Trpvicin																	TRPV3			99.4%
JNJ-17203212															TRPV1					99.44%
Ononetin									TRPM3, IC₅₀: 0.3 μM											99.54%
TRPV3 antagonist 74a																	TRPV3			99.85%
RN-1747							TRPM8, IC₅₀: 4.0 μM											hTRPV4, EC₅₀: 0.77 μM rTRPV4, EC₅₀: 4.1 μM mTRPV4, EC₅₀: 4.0 μM		99.27%
Larixyl acetate		hTRPC3, IC₅₀: 6.83 μM			hTRPC6, IC₅₀: 0.58 μM															99.44%
Crotamiton																		TRPV4		98.07%
Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside															TRPV1					98.92%
TRPV4 agonist-1 free base																		TRPV4		99.69%
(±)-Eriodictyol															rTRPV1					99.9%
SOR-C13 TFA																			TRPV6, IC₅₀: 14 nM	99.32%
4α-Phorbol 12,13-didecanoate																		TRPV4		99.30%
GFB-8438		hTRPC5, IC₅₀: 0.18 μM hTRPC4, IC₅₀: 0.29 μM rTRPC5, IC₅₀: 0.18 μM																		99.74%
Lazertinib mesylate	TRPA1																			99.85%
Phenamil methanesulfonate		TRPC3, IC₅₀: 140 nM																		98.1%
(1S,2S)-ML-SI3												TRPML1, IC₅₀: 5.9 μM	TRPML2, EC₅₀: 2.7 μM	TRPML3, EC₅₀: 10.8 μM						99.96%
M8-B							TRPM8													99.74%
Drofenine hydrochloride																	TRPV3			98.10%
MDR-652															hTRPV1, Ki: 11.4 nM rTRPV1, Ki: 23.8 nM hTRPV1, EC₅₀: 5.05 nM rTRPV1, EC₅₀: 93 nM					98.08%
ML204 hydrochloride			TRPC4	TRPC5																99.74%
TRPV1 antagonist 3							TRPM8, IC₅₀: 7.45 μM								hTRPV1, IC₅₀: 2.66 nM					99.30%
PF-04745637	TRPA1, IC₅₀: 17 nM																			99.97%
DMAPP triammonium																		TRPV4
ErSO-TFPy										TRPM4										99.33%
PF-05214030																		TRPV4		99.81%
Arvanil															TRPV1					99.1%
JW-65		TRPC3, IC₅₀: 0.37 μM																		99.05%
17(R)-Resolvin D1																	TRPV3, IC₅₀: 398 nM			99.69%
(R)-Methanandamide															TRPV1					99.61%
N-Arachidonyldopamine															TRPV1, EC₅₀: ~50 nM					98.36%
Capsiate															TRPV1					99.85%
Citronellyl acetate							TRPM8								TRPV1					98.0%
SOR-C13 acetate																			TRPV6, IC₅₀: 14 nM	99.11%
Protokylol hydrochloride															TRPV1					99.07%
LY3526318	TRPA1																			99.92%
TRPM7-IN-1											TRPM7/ChaK1									98.83%
TAT-M2NX								TRPM2												99.55%
Artepillin C	TRPA1, : 1.8 μM																			98.28%
L687		TRPC3			TRPC6	TRPC7														99.49%
Chembridge-5861528	TRPA1, IC₅₀: 14.3 μM (allyl isothiocyanate-evoked TRPA1 response) TRPA1, IC₅₀: 18.7 μM (4-HNE-evoked TRPA1 response)																			99.12%
AS1269574	TRPA1																			99.84%
Chrysin 6-C-glucoside 8-C-arabinoside															TRPV1					98.55%
1,4-Cineole	TRPA1						TRPM8
RN-1665																		hTRPV4, IC₅₀: 0.26 μM rTRPV4, IC₅₀: 0.39 μM		99.93%
N-Arachidonoyl Taurine															TRPV1, EC₅₀: 28 μM			TRPV4, Ki: 21 μM		99.0%
GSK2220691																		TRPV4
JTE-907															TRPV1					98.54%
MSP-3															TRPV1, EC₅₀: 0.87 μM					98.53%
Dexbrompheniramine															TRPV1					99.60%
Ricorfotide vedotin															TRPV6					98.45%
TRPA1-IN-2	TRPA1, IC₅₀: 0.04 μM																			99.82%
ProTx-I	TRPA1, IC₅₀: 389 nM
Libvatrep															TRPV1					99.54%
D-erythro-Sphingosine hydrochloride									TRPM3											99.95%
AM-0883					hTRPC6, EC₅₀: 46 nM
AM9053															TRPV1					98.36%
TRPM8-IN-1							TRPM8, IC₅₀: <5 μM													99.44%
1,4-Cineole (Standard)	TRPA1						TRPM8
TRPV4-IN-5																		TRPV4, IC₅₀: 0.46 μM		98.77%
L-R4W2															TRPV1, IC₅₀: 0.1 μM					98.13%
TRPV1 antagonist 10	TRPA1, IC₅₀: >100 μM						TRPM8, IC₅₀: 6.47 μM								TRPV1, IC₅₀: 36.47 nM TRPV3, IC₅₀: >100 μM TRPV4, IC₅₀: >100 μM
ZA18							TRPM2, IC₅₀: 6.2 μM
JNc-440																		TRPV4		98.04%
Dihydrocapsiate															TRPV1					99.33%
TRPA1 agonist-3	TRPA1, EC₅₀: 50.50 μM (human) TRPA1, EC₅₀: 314.04 μM (mouse)																			99.78%
TRPV6-IN-1																			TRPV6	99.1%
ABT-102															TRPV1					98.50%
Vanillyl butyl ether							TRPM8								TRPV1					99.75%
Rosiglitazone potassium				TRPC5, EC₅₀: 30 μM																99.13%
GSK3395879																		hTRPV4, IC₅₀: 1 nM
V116517															TRPV1
KS0365																	TRPV3, EC₅₀: 5.08 μM
ZA10								TRPM2, IC₅₀: 8.1 μM
FAAH/TRPV1 blocker-1															TRPV1, IC₅₀: 94.9 μM
Methyl kakuol	TRPA1
AG1529															TRPV1, IC₅₀: 0.93 μM
Polygodial pyridazine															TRPV1
AAL-149							TRPM7/ChaK1, IC₅₀: 1.081 μM
TRPV4 antagonist 4																		TRPV4, IC₅₀: 22.65 nM
Lazertinib mesylate hydrate	TRPA1
AMG-8562															TRPV1
TRPM8 receptor agonist-1							TRPM8
TRPM8 antagonist 4							TRPM8, IC₅₀: 42.3 nM
JTS-653															TRPV1
6-Iodonordihydrocapsaicin															TRPV1
TRPV4-KCa2.3 modulator 1																		TRPV4
TRPC antagonist 1		TRPC3, IC₅₀: 2.4 μM	TRPC4, IC₅₀: 12.2 μM	TRPC5, IC₅₀: 7.6 μM	TRPC6, IC₅₀: 2.9 μM	TRPC7, IC₅₀: 3.4 μM
TRPV3 antagonist-1																	TRPV3, IC₅₀: 11.97 μM
GSK3527497																		TRPV4
TRPV1-IN-2	TRPA1
L-R4W2 TFA															TRPV1, IC₅₀: 0.1 μM
CMP233							TRPM4, IC₅₀: 0.15 μM
Multitarget AD-IN-6	TRPA1
RN-9893 hydrochloride																		TRPV4
TRPC5-IN-5				TRPC5, IC₅₀: 1.28 μM
Neoambrosin	TRPA1
TRPC4/5-IN-1			TRPC4, IC₅₀: 2.06 μM	TRPC5, IC₅₀: 0.54 μM
TRPC5-IN-6				TRPC5
TL-119															TRPV1
TRPM8 antagonist 4 prodrug							TRPM8
TRPC4/5-IN-3			TRPC4, IC₅₀: 3.6 nM	TRPC5, IC₅₀: 5.5 nM																99.65%
Ovalicin															TRPV1
Artepillin C (Standard)	TRPA1, : 1.8 μM
TRPV4 antagonist 3																		TRPV4
ZQMT-10	TRPA1, Ki: 1.04 μM
KJM429															rTRPV1
MK-2295															TRPV1
GDC-0334	TRPA1
TRPC3 agonist-1		TRPC3
Cannabitwinol	TRPA1, EC₅₀: 3.0 μM						TRPM8, IC₅₀: 3.9 μM
ABT-116															TRPV1
SA-13353															TRPV1
TRPV1/CB2 agonist 1															TRPV1, EC₅₀: 26.8 μM
TRPV1 antagonist 5															TRPV1
AMG8788	TRPA1, IC₅₀: 1 μM
8,9-Epoxyeicosatrienoic acid	TRPA1
AMG9678	TRPA1, IC₅₀: 0.6 μM
TRPV1 antagonist 11															TRPV1, IC₅₀: 29.3 nM
TRPV4/TRPA1-IN-1	mTRPA, IC₅₀: 0.43 μM																	rTRPV4, IC₅₀: 0.45 μM
TRPM2-IN-2								TRPM2, IC₅₀: 0.66 μM
Drofenine																	TRPV3
DFL23448							TRPM8
HKC54																TRPV2, IC₅₀: 0.4 μM
GRC-6211															TRPV1
TRPM4-IN-4										TRPM4, IC₅₀: 0.339 μM
AZ12099548															hTRPV1
TRPC5-IN-4			TRPC4, IC₅₀: 65 nM	TRPC5, IC₅₀: 14.07 nM
(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide							TRPM8
BD-1063				TRPC5					TRPM3
HC-067047 hydrochloride																		TRPV4
N-Oleoyl valine																	TRPV3
Bisandrographolide A																		TRPV4, IC₅₀: 790-950 nM
20-Hydroxy-N-arachidonoyl taurine															TRPV1			TRPV4
2'-Deoxyadenosine-5'-O-diphosphoribose sodium								TRPM2
β-Sanshool															rTRPV1
4,5-Di-O-caffeoylquinic acid															TRPV1, EC₅₀: 69.34 μM
Carvacryl acetate	TRPA1																			99.80%
TRPC3/6-IN-1		hTRPC3, IC₅₀: 1260 nM hTRPC6, IC₅₀: 500 nM
TRPA1-IN-3	TRPA1																			99.66%

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